^
Association details:
| Biomarker: | MYCL overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | JQ-1 (BET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL
Excerpt:
Our aim was to analyse the antimyeloma activity of BET inhibitors on U266 cells. Two BET inhibitors, I-BET151 and JQ1, were tested. BET inhibitors decreased the cell proliferation in U266 cells with overexpression of MYCL less than those without overexpression of MYCL.
DOI:
10.1097/CAD.0000000000000389
