...the effect of JQ1 was explored in an aggressive, genetically-engineered model of Myc-dependent MM...two animals with advanced disease have completed 14 days of JQ1 treatment (25 mg/kg daily, adjusted to tolerability). Both animals reveal objective evidence of response by measurement of monotypic serum immunoglobulins, including a complete response (CR) in the second animal...An unexpected finding was the observed, robust inhibition of MYC expression following treatment with JQ1...