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Association details:
| Biomarker: | MYC expression |
|---|---|
| Cancer: | Medulloblastoma |
| Drug: | JHU395 (Glutamine antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
510 / 6 - Novel glutamine antagonist JHU-395 suppresses MYC-driven medulloblastoma growth and induces apoptosis
Excerpt:
We hypothesized that this prodrug would have enhanced cell penetration compared to DON and would kill MYC-expressing medulloblastoma. JHU-395 treatment caused decreased growth and increased apoptosis in human MYC-expressing medulloblastoma cell lines at lower concentrations than DON.
