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Association details:
| Biomarker: | MYC amplification |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | YPN-005 (CDK7 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 4849: YPN-005, an oral CDK7 inhibitor, shows a significant antitumor activity in Myc amplified solid tumors and MCL-1 overexpressed blood cancer
Excerpt:
Antiproliferative activity of YPN-005 was measured in solid tumor cell lines with Myc amplification and in hematologic cancer cells with MCL-1overexpression….YPN-005 significantly inhibited the proliferation of TNBC, ER+ breast cancer, HCC, ovarian cancer, small cell lung cancer (SCLC), pancreas, prostate and various types of blood cancer cells and IC50's were determined in 1-20 nM range.
DOI:
10.1158/1538-7445.AM2020-4849
