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BIOMARKER:
MYC amplification
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog
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Entrez ID:
4609
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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VERI cancer hierarchy
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MYC amplification
Non Small Cell Lung Cancer
MYC amplification
Non Small Cell Lung Cancer
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
gefitinib
Sensitive: B - Late Trials
gefitinib
Sensitive
:
B
MYC amplification
Small Cell Lung Cancer
MYC amplification
Small Cell Lung Cancer
AZD1775
Sensitive: C2 – Inclusion Criteria
AZD1775
Sensitive
:
C2
AZD1775
Sensitive: C2 – Inclusion Criteria
AZD1775
Sensitive
:
C2
MYC amplification
Esophageal Cancer
MYC amplification
Esophageal Cancer
ibrutinib
Sensitive: C2 – Inclusion Criteria
ibrutinib
Sensitive
:
C2
ibrutinib
Sensitive: C2 – Inclusion Criteria
ibrutinib
Sensitive
:
C2
MYC amplification
Melanoma
MYC amplification
Melanoma
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
MYC amplification
Ovarian Cancer
MYC amplification
Ovarian Cancer
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
durvalumab
Resistant: C3 – Early Trials
durvalumab
Resistant
:
C3
MYC amplification
Triple Negative Breast Cancer
MYC amplification
Triple Negative Breast Cancer
talazoparib
Resistant: C3 – Early Trials
talazoparib
Resistant
:
C3
talazoparib
Resistant: C3 – Early Trials
talazoparib
Resistant
:
C3
MYC amplification
Non Small Cell Lung Cancer
MYC amplification
Non Small Cell Lung Cancer
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
osimertinib
Resistant: C3 – Early Trials
osimertinib
Resistant
:
C3
MYC amplification
Ovarian Cancer
MYC amplification
Ovarian Cancer
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
MYC amplification
HER2 Positive Breast Cancer
MYC amplification
HER2 Positive Breast Cancer
trastuzumab + atezolizumab + pertuzumab
Resistant: C3 – Early Trials
trastuzumab + atezolizumab + pertuzumab
Resistant
:
C3
trastuzumab + atezolizumab + pertuzumab
Resistant: C3 – Early Trials
trastuzumab + atezolizumab + pertuzumab
Resistant
:
C3
MYC amplification
Squamous Cell Carcinoma of Head and Neck
MYC amplification
Squamous Cell Carcinoma of Head and Neck
nivolumab
Resistant: C4 – Case Studies
nivolumab
Resistant
:
C4
nivolumab
Resistant: C4 – Case Studies
nivolumab
Resistant
:
C4
MYC amplification
Acute Myelogenous Leukemia
MYC amplification
Acute Myelogenous Leukemia
venetoclax
Sensitive: C4 – Case Studies
venetoclax
Sensitive
:
C4
venetoclax
Sensitive: C4 – Case Studies
venetoclax
Sensitive
:
C4
MYC amplification
Small Cell Lung Cancer
MYC amplification
Small Cell Lung Cancer
talazoparib + GSK525762
Sensitive: D – Preclinical
talazoparib + GSK525762
Sensitive
:
D
talazoparib + GSK525762
Sensitive: D – Preclinical
talazoparib + GSK525762
Sensitive
:
D
MYC amplification
Triple Negative Breast Cancer
MYC amplification
Triple Negative Breast Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Hepatocellular Cancer
MYC amplification
Hepatocellular Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Estrogen Receptor Positive Breast Cancer
MYC amplification
Estrogen Receptor Positive Breast Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Pancreatic Cancer
MYC amplification
Pancreatic Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Prostate Cancer
MYC amplification
Prostate Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Small Cell Lung Cancer
MYC amplification
Small Cell Lung Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Ovarian Cancer
MYC amplification
Ovarian Cancer
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
YPN-005
Sensitive: D – Preclinical
YPN-005
Sensitive
:
D
MYC amplification
Small Cell Lung Cancer
MYC amplification
Small Cell Lung Cancer
ACR-368
Sensitive: D – Preclinical
ACR-368
Sensitive
:
D
ACR-368
Sensitive: D – Preclinical
ACR-368
Sensitive
:
D
MYC amplification
Medulloblastoma
MYC amplification
Medulloblastoma
PCM-075
Sensitive: D – Preclinical
PCM-075
Sensitive
:
D
PCM-075
Sensitive: D – Preclinical
PCM-075
Sensitive
:
D
MYC amplification
Small Cell Lung Cancer
MYC amplification
Small Cell Lung Cancer
APR-246
Sensitive: D – Preclinical
APR-246
Sensitive
:
D
APR-246
Sensitive: D – Preclinical
APR-246
Sensitive
:
D
MYC amplification
Ovarian Cancer
MYC amplification
Ovarian Cancer
KB-0742
Sensitive: D – Preclinical
KB-0742
Sensitive
:
D
KB-0742
Sensitive: D – Preclinical
KB-0742
Sensitive
:
D
MYC amplification
Colon Cancer
MYC amplification
Colon Cancer
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
MYC amplification
Hepatocellular Cancer
MYC amplification
Hepatocellular Cancer
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
MYC amplification
Gastric Cancer
MYC amplification
Gastric Cancer
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
MYC amplification
Esophageal Cancer
MYC amplification
Esophageal Cancer
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
MYC amplification
Head and Neck Cancer
MYC amplification
Head and Neck Cancer
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
KB-0742
Resistant: D – Preclinical
KB-0742
Resistant
:
D
MYC amplification
Solid Tumor
MYC amplification
Solid Tumor
RMC-5552
Sensitive: D – Preclinical
RMC-5552
Sensitive
:
D
RMC-5552
Sensitive: D – Preclinical
RMC-5552
Sensitive
:
D
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