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Association details:
| Biomarker: | MTOR F2108L |
|---|---|
| Cancer: | Thyroid Gland Carcinoma |
| Drug: | sirolimus (mTOR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer
Excerpt:
Cells expressing mTORF2108L were significantly more resistant to inhibition with rapamycin than were cells expressing nonmutant mTOR...In contrast to cells treated with rapamycin, cells expressing mTORF2108L and those expressing nonmutant mTOR were equally sensitive to treatment with torin 1...
DOI:
10.1056/NEJMoa1403352
