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    Association details:
    Biomarker:MSLN overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Pharmacol Res
    Title:

    Molecular Profiling of Afatinib-Resistant Non-Small Cell Lung Cancer Cells in vivo Derived from Mice

    Published date:
    09/04/2020
    Excerpt:
    Nude mice bearing subcutaneous NSCLC HCC827 tumors were administered with afatinib at different dose intensities (5-100 mg/kg)...As shown in Fig. 4, the expression levels of AXL, mesothelin (MSLN), and QPRT were significantly higher in the afatinib-resistant cells than in parental HCC827 cells.
    DOI:
    10.1016/j.phrs.2020.105183