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BIOMARKER:

MSI-L/dMMR + KRAS G12V

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Entrez ID:

Related biomarkers:

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MSI-H/dMMR (182)

MSI-H/dMMR + TMB-H (8)

STK11 deletion + KRAS mutation (6)

MSI-H/dMMR + TMB-L (5)

PTEN mutation + MSI-H/dMMR (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

MSI-H/dMMR + POLE mutation (4)

CPS1 overexpression + KRAS mutation + STK11 mutation (3)

HER-2 amplification + KRAS G12D (3)

KEAP1 deletion + KRAS mutation (3)

PD-L1 overexpression + KRAS mutation (3)

ARID1A mutation + MSI-H (3)

MSI-H/dMMR + MLH1 deletion + PMS2 deletion (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

EGFR exon 19 deletion + KRAS mutation (2)

KRAS G12C + PD-L1 underexpression (2)

KRAS mutation + PD-L1 negative (2)

BRAF V600E + MSI-H (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

AXL overexpression + KRAS G12C (1)

CDH2 overexpression + KRAS wild-type (1)

Chr t(11;14) + KRAS mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR expression + KRAS G12C (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

FGFR1 overexpression + KRAS G12C (1)

GNA13 deletion + KRAS mutation (1)

GOPC-ROS1 fusion + KRAS Q61H (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 overexpression + KRAS wild-type (1)

IGF1R overexpression + KRAS mutation (1)

IR overexpression + KRAS mutation (1)

IRS2 amplification + KRAS mutation (1)

KEAP1 mutation + KRAS wild-type (1)

KRAS A146 + TMB-H (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS G12D + Chr del(9)(p21) (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS G12D + TP53 deletion (1)

KRAS amplification + BRAF wild-type (1)

KRAS amplification + RAS wild-type (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + BCL2A1 overexpression (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + EGFR amplification (1)

KRAS mutation + ER expression (1)

KRAS mutation + HER-2 positive (1)

KRAS mutation + HR positive (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + PIK3CA wild-type (1)

KRAS mutation + PTPN11 overexpression (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

KRAS mutation + YKL-40 overexpression (1)

KRAS wild-type + BRAF V600E (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

KRAS mutation + STK11 mutation + AXL expression (1)

MLL-AFF1 fusion + KRAS mutation (1)

MSI-H/dMMR + KRAS G12D (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

MTAP deletion + KRAS G12C (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

POMK-NRG1 fusion + KRAS mutation (1)

POMK‐NRG1 fusion + KRAS G12D (1)

PTEN deletion + KRAS G12C (1)

RET positive + KRAS G12V (1)

ROS1 fusion + KRAS G12C (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

STRN-ALK fusion + KRAS G13D (1)

TP53 S12F + KRAS G12D + TMB-L (1)

B2M mutation + MSI-H/dMMR (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

JAK1 mutation + MSI-H/dMMR (1)

JAK2 mutation + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSH6 mutation + MLH1 mutation + MSI-H (1)

MSI-H + HER-2 amplification (1)

MSI-H + MSH2 expression + MSH6 expression (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + HER-2 mutation (1)

MSI-H/dMMR + KDR overexpression (1)

MSI-H/dMMR + MLH1 negative + PMS2 negative (1)

MSI-H/dMMR + NTRK1 fusion (1)

MSI-H/dMMR + NTRK2 fusion (1)

MSI-H/dMMR + NTRK3 fusion (1)

MSI-H/dMMR + PD-1 expression + CD8 positive (1)

MSI-H/dMMR + RAS mutation (1)

MSI-H/dMMR + TP53 mutation (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 expression + MSI-H/dMMR (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

HER-2 amplification + KRAS G12C (0)

PRMT5 overexpression + KRAS mutation (0)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

MSI-H/dMMR + RAS wild-type (0)

MSI-L/dMMR + SMAD4 mutation (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

MSI-H/dMMR (182)

MSI-H/dMMR + TMB-H (8)

STK11 deletion + KRAS mutation (6)

MSI-H/dMMR + TMB-L (5)

PTEN mutation + MSI-H/dMMR (5)

KRAS G12C + PD-L1 overexpression (4)

KRAS mutation + PD-L1 expression (4)

MSI-H/dMMR + POLE mutation (4)

CPS1 overexpression + KRAS mutation + STK11 mutation (3)

HER-2 amplification + KRAS G12D (3)

KEAP1 deletion + KRAS mutation (3)

PD-L1 overexpression + KRAS mutation (3)

ARID1A mutation + MSI-H (3)

MSI-H/dMMR + MLH1 deletion + PMS2 deletion (3)

MSI-H/dMMR + TMB-H + PD-L1 negative (3)

EGFR exon 19 deletion + KRAS mutation (2)

KRAS G12C + PD-L1 underexpression (2)

KRAS mutation + PD-L1 negative (2)

BRAF V600E + MSI-H (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)

AXL overexpression + KRAS G12C (1)

CDH2 overexpression + KRAS wild-type (1)

Chr t(11;14) + KRAS mutation (1)

EGFR C797S + KRAS amplification + RB1 deletion (1)

EGFR L858R + KRAS amplification + RB1 deletion (1)

EGFR T790M + KRAS amplification + RB1 deletion (1)

EGFR V843I + KRAS G13D + AKT1 E17K + PD-L1 overexpression (1)

EGFR exon 19 deletion + TP53 mutation + CDK6 amplification + KRAS amplification (1)

EGFR expression + KRAS G12C (1)

EGFR overexpression + KRAS 13D (1)

EGFR overexpression + KRAS mutation (1)

FGFR1 overexpression + KRAS G12C (1)

GNA13 deletion + KRAS mutation (1)

GOPC-ROS1 fusion + KRAS Q61H (1)

HER-2 amplification + KRAS exon 2 wild-type (1)

HER-2 amplification + KRAS wild-type (1)

HER-2 overexpression + KRAS wild-type (1)

IGF1R overexpression + KRAS mutation (1)

IR overexpression + KRAS mutation (1)

IRS2 amplification + KRAS mutation (1)

KEAP1 mutation + KRAS wild-type (1)

KRAS A146 + TMB-H (1)

KRAS G12C + PD-L1 expression (1)

KRAS G12C + PD-L1 underexpression + STK11 mutation (1)

KRAS G12D + Chr del(9)(p21) (1)

KRAS G12D + HER-2 amplification + TMB-H (1)

KRAS G12D + TP53 deletion (1)

KRAS amplification + BRAF wild-type (1)

KRAS amplification + RAS wild-type (1)

KRAS mutation + PTPN11 overexpression + PD-L1 overexpression (1)

KRAS mutation + BCL2A1 overexpression (1)

KRAS mutation + CDK9 overexpression + HR positive (1)

KRAS mutation + EGFR amplification (1)

KRAS mutation + ER expression (1)

KRAS mutation + HER-2 positive (1)

KRAS mutation + HR positive (1)

KRAS mutation + PD-L1 underexpression (1)

KRAS mutation + PIK3CA wild-type (1)

KRAS mutation + PTPN11 overexpression (1)

KRAS mutation + TP53 mutation + GNA13 deletion (1)

KRAS mutation + TP53 mutation + PD-L1 expression + PD-1 expression (1)

KRAS mutation + YKL-40 overexpression (1)

KRAS wild-type + BRAF V600E (1)

KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)

KRAS mutation + STK11 mutation + AXL expression (1)

MLL-AFF1 fusion + KRAS mutation (1)

MSI-H/dMMR + KRAS G12D (1)

MSI-H/dMMR + KRAS Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

MTAP deletion + KRAS G12C (1)

PD-L1 negative + KRAS G12C (1)

PD-L1 overexpression + KRAS G12C + TP53 mutation (1)

POMK-NRG1 fusion + KRAS mutation (1)

POMK‐NRG1 fusion + KRAS G12D (1)

PTEN deletion + KRAS G12C (1)

RET positive + KRAS G12V (1)

ROS1 fusion + KRAS G12C (1)

STK11 mutation + KRAS mutation + TP53 deletion (1)

STRN-ALK fusion + KRAS G13D (1)

TP53 S12F + KRAS G12D + TMB-L (1)

B2M mutation + MSI-H/dMMR (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)

JAK1 mutation + MSI-H/dMMR (1)

JAK2 mutation + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR (1)

MLH1 methylation + MSI-H/dMMR + TMB-H (1)

MSH6 mutation + MLH1 mutation + MSI-H (1)

MSI-H + HER-2 amplification (1)

MSI-H + MSH2 expression + MSH6 expression (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + HER-2 mutation (1)

MSI-H/dMMR + KDR overexpression (1)

MSI-H/dMMR + MLH1 negative + PMS2 negative (1)

MSI-H/dMMR + NTRK1 fusion (1)

MSI-H/dMMR + NTRK2 fusion (1)

MSI-H/dMMR + NTRK3 fusion (1)

MSI-H/dMMR + PD-1 expression + CD8 positive (1)

MSI-H/dMMR + RAS mutation (1)

MSI-H/dMMR + TP53 mutation (1)

NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)

PD-L1 expression + MSI-H/dMMR (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)

TMB-H + PD-L1 expression + MSI-L/dMMR (1)

HER-2 amplification + KRAS G12C (0)

PRMT5 overexpression + KRAS mutation (0)

AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)

MSI-H/dMMR + RAS wild-type (0)

MSI-L/dMMR + SMAD4 mutation (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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MSI-L/dMMR + KRAS G12V	Colorectal Cancer	MSI-L/dMMR + KRAS G12V	Colorectal Cancer	nivolumab + ipilimumab + regorafenib Sensitive: C4 – Case Studies nivolumab + ipilimumab + regorafenib Sensitive : C4	nivolumab + ipilimumab + regorafenib Sensitive: C4 – Case Studies nivolumab + ipilimumab + regorafenib Sensitive : C4
MSI-L/dMMR + KRAS G12V	Colorectal Cancer	MSI-L/dMMR + KRAS G12V	Colorectal Cancer	Resistant: C4 – Case Studies Resistant : C4	Resistant: C4 – Case Studies Resistant : C4