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BIOMARKER:
MSI-H/dMMR + KDR overexpression
i
Other names:
MSI | Microsatellite instability, KDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor (a type III receptor tyrosine kinase)
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Entrez ID:
3791
Related biomarkers:
Expression
Mutation
CNA
Others
‹
MSI-H/dMMR (182)
MSI-H/dMMR + TMB-H (8)
MSI-L/dMMR (6)
MSI-H/dMMR + TMB-L (5)
PTEN mutation + MSI-H/dMMR (5)
MSI-H/dMMR + POLE mutation (4)
ARID1A mutation + MSI-H (3)
MSI-H/dMMR + MLH1 deletion + PMS2 deletion (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
BRAF V600E + MSI-H (2)
BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
MSI-L/dMMR + KRAS G12V (2)
KDR elevation (2)
B2M mutation + MSI-H/dMMR (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
JAK1 mutation + MSI-H/dMMR (1)
JAK2 mutation + MSI-H/dMMR (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
MLH1 methylation + MSI-H/dMMR (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSH6 mutation + MLH1 mutation + MSI-H (1)
MSI-H + HER-2 amplification (1)
MSI-H + MSH2 expression + MSH6 expression (1)
MSI-H/dMMR + BRAF Mutation (1)
MSI-H/dMMR + HER-2 mutation (1)
MSI-H/dMMR + KRAS Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
MSI-H/dMMR + MLH1 negative + PMS2 negative (1)
MSI-H/dMMR + NTRK1 fusion (1)
MSI-H/dMMR + NTRK2 fusion (1)
MSI-H/dMMR + NTRK3 fusion (1)
MSI-H/dMMR + PD-1 expression + CD8 positive (1)
MSI-H/dMMR + RAS mutation (1)
MSI-H/dMMR + TP53 mutation (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 expression + MSI-H/dMMR (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
EGFR L858R + KDR overexpression + VEGFC overexpression (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
MSI-H/dMMR + RAS wild-type (0)
MSI-L/dMMR + SMAD4 mutation (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
MSI-H/dMMR (182)
MSI-H/dMMR + TMB-H (8)
MSI-L/dMMR (6)
MSI-H/dMMR + TMB-L (5)
PTEN mutation + MSI-H/dMMR (5)
MSI-H/dMMR + POLE mutation (4)
ARID1A mutation + MSI-H (3)
MSI-H/dMMR + MLH1 deletion + PMS2 deletion (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
BRAF V600E + MSI-H (2)
BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
MSI-L/dMMR + KRAS G12V (2)
KDR elevation (2)
B2M mutation + MSI-H/dMMR (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
JAK1 mutation + MSI-H/dMMR (1)
JAK2 mutation + MSI-H/dMMR (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
MLH1 methylation + MSI-H/dMMR (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSH6 mutation + MLH1 mutation + MSI-H (1)
MSI-H + HER-2 amplification (1)
MSI-H + MSH2 expression + MSH6 expression (1)
MSI-H/dMMR + BRAF Mutation (1)
MSI-H/dMMR + HER-2 mutation (1)
MSI-H/dMMR + KRAS Mutation (1)
MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)
MSI-H/dMMR + MLH1 negative + PMS2 negative (1)
MSI-H/dMMR + NTRK1 fusion (1)
MSI-H/dMMR + NTRK2 fusion (1)
MSI-H/dMMR + NTRK3 fusion (1)
MSI-H/dMMR + PD-1 expression + CD8 positive (1)
MSI-H/dMMR + RAS mutation (1)
MSI-H/dMMR + TP53 mutation (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 expression + MSI-H/dMMR (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
SMARCA4 deletion + dMMR/MSI-H + PD-L1 underexpression (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
EGFR L858R + KDR overexpression + VEGFC overexpression (1)
KDR amplification + FLT4 amplification + MCL1 amplification + TP53 R213 + TP53 H179Y + ARID1A Q2128 (1)
AKT1 E17K + CTNNB1 G34R + ER Y537S + MSI-H (0)
MSI-H/dMMR + RAS wild-type (0)
MSI-L/dMMR + SMAD4 mutation (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
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MSI-H/dMMR + KDR overexpression
Solid Tumor
MSI-H/dMMR + KDR overexpression
Solid Tumor
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
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