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DRUG CLASS:

MLL1 inhibitor

DRUG CLASS:

MLL1 inhibitor

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NPM1 mutation	Leukemia	NPM1 mutation	Leukemia	JNJ-6617 Sensitive: C3 – Early Trials JNJ-6617 Sensitive : C3	JNJ-6617 Sensitive: C3 – Early Trials JNJ-6617 Sensitive : C3
KMT2A mutation	Leukemia	KMT2A mutation	Leukemia	JNJ-6617 Sensitive: C3 – Early Trials JNJ-6617 Sensitive : C3	JNJ-6617 Sensitive: C3 – Early Trials JNJ-6617 Sensitive : C3
NPM1 mutation	Acute Myelogenous Leukemia	NPM1 mutation	Acute Myelogenous Leukemia	venetoclax + JNJ-6617 Sensitive: D – Preclinical venetoclax + JNJ-6617 Sensitive : D	venetoclax + JNJ-6617 Sensitive: D – Preclinical venetoclax + JNJ-6617 Sensitive : D
KMT2A mutation	Acute Myelogenous Leukemia	KMT2A mutation	Acute Myelogenous Leukemia	venetoclax + JNJ-6617 Sensitive: D – Preclinical venetoclax + JNJ-6617 Sensitive : D	venetoclax + JNJ-6617 Sensitive: D – Preclinical venetoclax + JNJ-6617 Sensitive : D