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Association details:
| Biomarker: | MLL rearrangement |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | irinotecan (Topoisomerase I inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia
Published date:
06/23/2021
Excerpt:
...Irinotecan monotherapy was able to induce sustainable disease remissions in MLL-rearranged ALL xenotransplanted mice burdened with advanced leukemia. Taken together, our data demonstrate that Irinotecan exerts highly potent anti-leukemia effects against pediatric MLL-rearranged ALL
DOI:
10.3390/biomedicines9070711
