^
BIOMARKER:

MLL mutation

i
Other names: HTRX1, HTRX, MLL1A, Mixed Lineage Leukemia 1, Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 1, CXXC7, MLL1, TRX1, Zinc Finger Protein HRX, Trithorax-Like Protein, ALL-1, Lysine (K)-Specific Methyltransferase 2A, CXXC-Type Zinc Finger Protein 7, Histone-Lysine N-Methyltransferase 2A, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, Lysine Methyltransferase 2A, MLL, Myeloid/Lymphoid Or Mixed-Lineage Leukemia, KMT2A
MLL mutation
AML
abemaciclib + KO-539
Sensitive: D – Preclinical
MLL mutation
AML
KO-539 + OTX015
Sensitive: D – Preclinical
MLL mutation
AML
venetoclax + KO-539
Sensitive: D – Preclinical