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Association details:
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
Title:

Use of plasma ctDNA as a potential biomarker for longitudinal monitoring of a patient with metastatic high-risk upper tract urothelial carcinoma receiving pembrolizumab and personalized neoepitope-derived multipeptide vaccinations: a case report

Published date:
01/11/2021
Excerpt:
... 55-year-old man who was diagnosed with high-risk metastatic UTUC in 2015...mutated molecules per mL plasma (MM/mL) of a known tumor-specific variant in the MLH1 gene by ddPCR...When MRI scans proved tumor recurrence, treatment with pembrolizumab was started again leading to a rapid decrease of MM/mL in the pLB to again zero. Treatment response was then also confirmed by MRI.
DOI:
10.1136/jitc-2020-001406