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BIOMARKER:
MET Y1230C
i
Other names:
DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MET amplification + EGFR mutation (8)
EGFR mutation + MET amplification (5)
ALK rearrangement + MET amplification (3)
EGFR mutation + MET overexpression (3)
MET amplification + MET Exon 14 mutation (3)
MET elevation (3)
MET overexpression + EGFR mutation (3)
BRAF mutation + MET amplification (2)
CD74-ROS1 fusion + MET D1228N + MET amplification (2)
EGFR exon 19 deletion + MET amplification (2)
EGFR exon 19 deletion + MET Amplification + MET D1228V (2)
MET amplification + MET overexpression (2)
PD-L1 overexpression + MET exon 14 mutation (2)
STRN-ALK fusion + MET amplification (2)
ALK rearrangement + MET amplification (1)
CAPZA2-MET fusion + MET amplification (1)
EGFR C797S + MET amplification (1)
EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)
EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)
EGFR L858R + MET amplification (1)
EGFR L858R + MET overexpression (1)
EGFR L858R + MET positive (1)
EGFR T263P + EGFR L858R + MET amplification (1)
EGFR T790M + MET amplification (1)
EGFR T790M + MET positive (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + MET positive (1)
EGFR exon 19 deletion + MET amplification (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
EGFR mutation + MET amplification + EGFR amplification (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + MET overexpression + MET amplification (1)
EGFR mutation + MET-CEP7 fusion (1)
EGFR wild-type + MET amplification (1)
EGFR wild-type + MET overexpression (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
KIAA1549-BRAF fusion + MET amplification (1)
KIF5B-RET fusion + MET amplification (1)
MET amplification + KLC1-ALK fusion (1)
MET amplification + MET exon 14 mutation + EGFR exon 20 insertion (1)
MET amplification + PIK3CA mutation (1)
MET amplification + RB1 wild-type (1)
MET amplification + RET fusion (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MET exon 14 mutation + ALK wild-type (1)
MET exon 14 mutation + EGFR wild-type (1)
MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)
MET exon 14 mutation + MET overexpression (1)
MET mutation + TMB-H (1)
MET negative + EGFR mutation (1)
MET overexpression + EGFR wild-type (1)
MET positive + EGFR mutation (1)
PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)
ROS1 positive + MET amplification (1)
TFE3 rearrangement + MET expression (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
MET-H (0)
MET amplification + EGFR mutation (8)
EGFR mutation + MET amplification (5)
ALK rearrangement + MET amplification (3)
EGFR mutation + MET overexpression (3)
MET amplification + MET Exon 14 mutation (3)
MET elevation (3)
MET overexpression + EGFR mutation (3)
BRAF mutation + MET amplification (2)
CD74-ROS1 fusion + MET D1228N + MET amplification (2)
EGFR exon 19 deletion + MET amplification (2)
EGFR exon 19 deletion + MET Amplification + MET D1228V (2)
MET amplification + MET overexpression (2)
PD-L1 overexpression + MET exon 14 mutation (2)
STRN-ALK fusion + MET amplification (2)
ALK rearrangement + MET amplification (1)
CAPZA2-MET fusion + MET amplification (1)
EGFR C797S + MET amplification (1)
EGFR G719D + EGFR L861Q + CUX1-MET fusion (1)
EGFR L747_A750delinsP + MET D1228H + MET D1228N + MET D1228Y + MET Y1230H + MET amplification (1)
EGFR L858R + MET amplification (1)
EGFR L858R + MET overexpression (1)
EGFR L858R + MET positive (1)
EGFR T263P + EGFR L858R + MET amplification (1)
EGFR T790M + MET amplification (1)
EGFR T790M + MET positive (1)
EGFR T790M + STRN-ALK fusion + EGFR amplification + MET amplification (1)
EGFR exon 19 deletion + MET positive (1)
EGFR exon 19 deletion + MET amplification (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y (1)
EGFR exon 19 deletion + MET amplification + MET D1228H + MET D1228N + MET D1228Y + MET Y1230C (1)
EGFR exon 19 deletion + TP53 mutation + MET amplification (1)
EGFR mutation + EGFR amplification + MET amplification + MTAP deletion (1)
EGFR mutation + MET amplification + EGFR amplification (1)
EGFR mutation + MET amplification + TP53 mutation (1)
EGFR mutation + MET overexpression + MET amplification (1)
EGFR mutation + MET-CEP7 fusion (1)
EGFR wild-type + MET amplification (1)
EGFR wild-type + MET overexpression (1)
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation (1)
KIAA1549-BRAF fusion + MET amplification (1)
KIF5B-RET fusion + MET amplification (1)
MET amplification + KLC1-ALK fusion (1)
MET amplification + MET exon 14 mutation + EGFR exon 20 insertion (1)
MET amplification + PIK3CA mutation (1)
MET amplification + RB1 wild-type (1)
MET amplification + RET fusion (1)
MET amplification + TP53 mutation (1)
MET amplification + TP53 mutation + SMAD4 mutation + CTNNA1 mutation (1)
MET exon 14 mutation + ALK wild-type (1)
MET exon 14 mutation + EGFR wild-type (1)
MET exon 14 mutation + MET amplification + PD-L1 overexpression (1)
MET exon 14 mutation + MET overexpression (1)
MET mutation + TMB-H (1)
MET negative + EGFR mutation (1)
MET overexpression + EGFR wild-type (1)
MET positive + EGFR mutation (1)
PTGS2 positive + MET positive + PBK positive + EGFR mutation (1)
ROS1 positive + MET amplification (1)
TFE3 rearrangement + MET expression (1)
TP53 mutation + MET amplification + PD-L1 overexpression (1)
MET-H (0)
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VERI cancer hierarchy
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MET Y1230C
Non Small Cell Lung Cancer
MET Y1230C
Non Small Cell Lung Cancer
osimertinib + savolitinib + REGN5093-M114
Sensitive: D – Preclinical
osimertinib + savolitinib + REGN5093-M114
Sensitive
:
D
osimertinib + savolitinib + REGN5093-M114
Sensitive: D – Preclinical
osimertinib + savolitinib + REGN5093-M114
Sensitive
:
D
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