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Association details:
| Biomarker: | MET exon 14 mutation + EGFR exon 20 insertion |
|---|---|
| Cancer: | Lung Non-Small Cell Squamous Cancer |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Rapid Disease Progression in a Patient with Advanced NSCLC Harboring a Germline MET Exon 14 Skipping Mutation: A Case Report
Published date:
04/07/2021
Excerpt:
...33-year-old NSCLC patient with a germline MET exon 14 skipping mutation, who also harbored a somatic EGFR exon 20 insertion. The patient was initially diagnosed with a stage IIB adenosquamous carcinoma....Afatinib was then prescribed but disease progressed immediately.
DOI:
https://doi.org/10.2147/OTT.S295542
