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Association details:
Biomarker:MELK overexpression
Cancer:Diffuse Large B Cell Lymphoma
Regimen:R-CHOP (cyclophosphamide + doxorubicin hydrochloride + prednisone + Rituxan (rituximab) + vincristine)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Title:

Maternal embryonic leucine zipper kinase is a novel target for diffuse large B cell lymphoma and mantle cell lymphoma

Published date:
11/18/2019
Excerpt:
...high MELK expression levels were associated with a significant worse survival in DLBCL patients (93 ABC-, 108 GCB-, and 32 unclassified DLBCL patients) receiving R-CHOP treatment…
DOI:
https://doi.org/10.1038/s41408-019-0249-x