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DRUG CLASS:

MDM2-p53 antagonist

DRUG CLASS:

MDM2-p53 antagonist

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MDM2 amplification	Liposarcoma	MDM2 amplification	Liposarcoma	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
TP53 wild-type	Solid Tumor	TP53 wild-type	Solid Tumor	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Solid Tumor	MDM2 amplification	Solid Tumor	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Cholangiocarcinoma	MDM2 amplification	Cholangiocarcinoma	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Biliary Tract Cancer	MDM2 amplification	Biliary Tract Cancer	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Solid Tumor	MDM2 amplification	Solid Tumor	BI 907828 + BI 754091 Sensitive: C3 – Early Trials BI 907828 + BI 754091 Sensitive : C3	BI 907828 + BI 754091 Sensitive: C3 – Early Trials BI 907828 + BI 754091 Sensitive : C3
MDM2 amplification	Ampulla of Vater Carcinoma	MDM2 amplification	Ampulla of Vater Carcinoma	BI 907828 Sensitive: C3 – Early Trials BI 907828 Sensitive : C3	BI 907828 Sensitive: C3 – Early Trials BI 907828 Sensitive : C3
MDM2 amplification + TP53 wild-type	Liposarcoma	MDM2 amplification + TP53 wild-type	Liposarcoma	BI 907828 Sensitive: C3 – Early Trials BI 907828 Sensitive : C3	BI 907828 Sensitive: C3 – Early Trials BI 907828 Sensitive : C3
MDM2 amplification	Glioblastoma	MDM2 amplification	Glioblastoma	BI 907828 Sensitive: D – Preclinical BI 907828 Sensitive : D	BI 907828 Sensitive: D – Preclinical BI 907828 Sensitive : D