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BIOMARKER:

MDM2 amplification

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MDM2 amplification	Liposarcoma	MDM2 amplification	Liposarcoma	APG-115 Sensitive: C2 – Inclusion Criteria APG-115 Sensitive : C2	APG-115 Sensitive: C2 – Inclusion Criteria APG-115 Sensitive : C2
MDM2 amplification	Solid Tumor	MDM2 amplification	Solid Tumor	RAIN-32 Sensitive: C2 – Inclusion Criteria RAIN-32 Sensitive : C2	RAIN-32 Sensitive: C2 – Inclusion Criteria RAIN-32 Sensitive : C2
MDM2 amplification	Liposarcoma	MDM2 amplification	Liposarcoma	RAIN-32 Sensitive: C2 – Inclusion Criteria RAIN-32 Sensitive : C2	RAIN-32 Sensitive: C2 – Inclusion Criteria RAIN-32 Sensitive : C2
MDM2 amplification	Liposarcoma	MDM2 amplification	Liposarcoma	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Sarcoma	MDM2 amplification	Sarcoma	RAIN-32 Sensitive: C2 – Inclusion Criteria RAIN-32 Sensitive : C2	RAIN-32 Sensitive: C2 – Inclusion Criteria RAIN-32 Sensitive : C2
MDM2 amplification	Solid Tumor	MDM2 amplification	Solid Tumor	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Cholangiocarcinoma	MDM2 amplification	Cholangiocarcinoma	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Biliary Tract Cancer	MDM2 amplification	Biliary Tract Cancer	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2	BI 907828 Sensitive: C2 – Inclusion Criteria BI 907828 Sensitive : C2
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3	ipilimumab Resistant: C3 – Early Trials ipilimumab Resistant : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3	nivolumab + ipilimumab Resistant: C3 – Early Trials nivolumab + ipilimumab Resistant : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3	nivolumab Resistant: C3 – Early Trials nivolumab Resistant : C3
MDM2 amplification	Mucosal Melanoma	MDM2 amplification	Mucosal Melanoma	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3
MDM2 amplification	Gastric Adenocarcinoma	MDM2 amplification	Gastric Adenocarcinoma	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3
MDM2 amplification	Diffuse Large B Cell Lymphoma	MDM2 amplification	Diffuse Large B Cell Lymphoma	R-CHOP Resistant: C3 – Early Trials R-CHOP Resistant : C3	R-CHOP Resistant: C3 – Early Trials R-CHOP Resistant : C3
MDM2 amplification	Solid Tumor	MDM2 amplification	Solid Tumor	BI 907828 + BI 754091 Sensitive: C3 – Early Trials BI 907828 + BI 754091 Sensitive : C3	BI 907828 + BI 754091 Sensitive: C3 – Early Trials BI 907828 + BI 754091 Sensitive : C3
MDM2 amplification	Ampulla of Vater Carcinoma	MDM2 amplification	Ampulla of Vater Carcinoma	BI 907828 Sensitive: C3 – Early Trials BI 907828 Sensitive : C3	BI 907828 Sensitive: C3 – Early Trials BI 907828 Sensitive : C3
MDM2 amplification	Triple Negative Breast Cancer	MDM2 amplification	Triple Negative Breast Cancer	pembrolizumab Resistant: C4 – Case Studies pembrolizumab Resistant : C4	pembrolizumab Resistant: C4 – Case Studies pembrolizumab Resistant : C4
MDM2 amplification	Hormone Receptor Positive Breast Cancer	MDM2 amplification	Hormone Receptor Positive Breast Cancer	RAIN-32 Sensitive: D – Preclinical RAIN-32 Sensitive : D	RAIN-32 Sensitive: D – Preclinical RAIN-32 Sensitive : D