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Association details:
| Biomarker: | MCT1 overexpression + SLC16A3 overexpression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | metformin (AMPK activator) + syrosingopine (MCT1 inhibitor, MCT4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
INHIBITION OF LACTATE EXPORTERS INDUCES DIRECT ANTI-TUMOR EFFECTS AND COUNTERS IMMUNE SUPPRESSION IN MULTIPLE MYELOMA
Published date:
05/12/2022
Excerpt:
Increased expression of MCT1 and MCT4 was observed in MM cell lines after 48 hours of hypoxia...MM cells could however be sensitized to syrosingopine by treatment with metformin, a complex I inhibitor, resulting in apoptosis….Dual inhibition of MCT1 and MCT4 is not sufficient to induce apoptosis in MM cells; however, they can be sensitized to syrosingopine with metformin.
