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Association details:
| Biomarker: | KRT19 elevation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Teysuno (gimeracil/oteracil/tegafur) (Thymidylate synthase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Predictive role of CYFRA 21-1 for S-1 monotherapy in non-small cell lung cancer patients
Published date:
04/21/2022
Excerpt:
We retrospectively screened 108 patients with advanced non-small cell lung cancer (NSCLC) treated via S-1 monotherapy…. Sixty-one patients with high CYFRA 21-1 levels had a statistically significant shorter progression-free survival (PFS) and overall survival (OS) than 46 patients with normal levels (median PFS = 42 days vs. 70 days, respectively; p = 0.0014; median OS = 197 days vs. 316 days, respectively, p = 0.0239)....Serum CYFRA 21-1 levels have predictive and prognostic roles in the management of patients with advanced NSCLC on S-1 monotherapy.
DOI:
https://doi.org/10.1016/j.resinv.2021.11.014
