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    Association details:
    Biomarker:KRT14 underexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:hydroxyureamethylacylfulvene (STAR-001) (Alkylating agent)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    ASCO 2020
    Title:

    Correlation of gene expression profile to identify tumors with extreme sensitivity to the alkylating agent LP184.

    Published date:
    05/28/2020
    Excerpt:
    Differential sensitivity and gene expression pattern analyses on NSCLC cell lines correlated with high relative expression of PTGR1, CASP6, NAMPT, SMARCD3 and GLRX genes along with low relative expression of KMD4A, HPGD, PTPRF and KRT14 genes in the highly sensitive cell lines. 
    DOI:
    10.1200/JCO.2020.38.15_suppl.e21021