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Association details:
| Biomarker: | KRAS mutation |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | SCH772984 (ERK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors
Excerpt:
Dose-dependent antitumor activity was also observed in the KRAS-mutant pancreatic MiaPaCa model, with 36% regression at 50 mg/kg twice daily...
DOI:
10.1158/2159-8290.CD-13-0070
