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Association details:
| Biomarker: | KRAS mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | JQ-1 (BET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer
Excerpt:
Among mice with kras-mutant tumors, single-agent JQ1 provoked a partial response in 100% of treated animals, defined by a greater than 30% reduction in tumor volume (Fig. 5A and B). Mice bearing kras-mutant tumors responded significantly better than mice with mutant kras tumors with concurrent lkb1 loss (Fig. 5A and B; Fisher exact test, P = 0.015)...
DOI:
10.1158/1078-0432.CCR-12-3904
