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Association details:
| Biomarker: | KRAS mutation |
|---|---|
| Cancer: | Melanoma |
| Drug: | SCH772984 (ERK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors
Excerpt:
In vivo antitumor efficacy of SCH772984 was evaluated in BRAF- or KRAS-mutant xenograft models established from human melanoma or pancreatic carcinoma cell lines.In vivo antitumor efficacy of SCH772984 was evaluated in BRAF- or KRAS-mutant xenograft models established from human melanoma or pancreatic carcinoma cell lines. Treatment of BRAF-mutant LOX melanoma xenografts with SCH772984 (50 mg/kg twice daily) led to 98% tumor regression,
DOI:
10.1158/2159-8290.CD-13-0070
