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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Source:
Title:

Eltanexor (KPT-8602), a second-generation selective inhibitor of nuclear export (SINE) compound, in patients with metastatic colorectal cancer (mCRC)

Excerpt:
Pts with mCRC (≥50% KRAS mutant) in expansion cohorts received once daily oral ELTAfor 5 days per week at 20 (n = 7) or 30 (n = 23) mg….ELTA is well-tolerated with manageable AEs in mCRC. Even though this was small sample size, ELTA shows promise with a longer median PFS in this heavily treated population when compared to the currently available 3rdline therapies.
DOI:
10.1093/annonc/mdy424.024
Trial ID: