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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

P18: Phase II Trial of Regorafenib and Oral Methotrexate in Previously Treated Advanced KRAS Mutant Non-Small Cell Lung Cancer

Published date:
01/28/2022
Excerpt:
Overall, 3 partial responses were observed (2 with KRAS G12D, 1 with KRAS G12R); the objective response rate was 16.7% (95% CI 4.0-41.4). At 8 weeks, the disease control rate was 66.7% (95% CI 41.0-86.7)….Combination treatment of regorafenib and oral methotrexate in patients with KRAS mutant NSCLC was limited due to toxicity.
Secondary therapy:
methotrexate
Trial ID: