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Association details:
| Biomarker: | KRAS G12D |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | ABT-737 (Bcl2 antagonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model
Published date:
12/09/2021
Excerpt:
...the effectiveness of the BH3 mimetic ABT-737 as a radiosensitizer using K-ras mutant non-small cell lung cancer (NSCLC) cells and a KrasG12D:p53fl/fl mouse (KP mouse) model....In the KP mouse lung cancer model, cotreatment with ABT-737 and radiation-induced significant tumor regression....These findings supported the radiosensitizing activity of ABT-737 in preclinical models, and suggested that clinical trials using this strategy may be beneficial in K-ras mutant NSCLC.
DOI:
10.3349/ymj.2022.63.1.16
