^
Association details:
Biomarker:KRAS G12D
Cancer:Biliary Tract Cancer
Drug:Koselugo (selumetinib) (MEK inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

Multi-Institutional Phase II Study of Selumetinib in Patients With Metastatic Biliary Cancers

Excerpt:
This was a multi-institutional phase II study of selumetinib at 100 mg given orally twice per day to patients with advanced BC….Two patients with short-lived SD had KRAS mutations….Of the 25 samples successfully evaluated for KRAS G12/13X mutations, two were positive, which indicates the presence of G12S and G12D mutations.
DOI:
https://dx.doi.org/10.1200%2FJCO.2010.33.9473
Trial ID: