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Association details:
| Biomarker: | KRAS G12C |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | Mekinist (trametinib) (MEK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Radiation combined with KRAS-MEK inhibitors enhances anticancer immunity in KRAS-mutated tumor models
Published date:
08/06/2022
Excerpt:
...we investigated the additive effect of radiation and KRAS-MEK inhibitors (AMG510 and trametinib) in KRAS-mutated tumors....The four human cancer cell lines with the KRAS G12C mutation had different sensitivities to AMG510, and the CCK-8 assay showed that miapaca2 and H358 cells were more sensitive to AMG510 than the other cell lines (Figure 1B) and were also sensitive to MEKi...
DOI:
https://doi.org/10.1016/j.trsl.2022.08.005
