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Association details:
| Biomarker: | KRAS G12C |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | OTS514 (TOPK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
KRASG12C mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer
Published date:
05/24/2023
Excerpt:
...we found that OTS514 and 5-FU could induce apoptosis in KRASG12C cells, and the combination of OTS514 and 5-FU showed strong synergistic effect in apoptosis induction...we found that the combination of OTS514 + 5-FU induced more apoptotic cells and showed a more profound inhibition on cell proliferation in KRASG12C cells when compared with KRASWT cells (Figure 6E,F). The synergistic effect of OTS514 and 5-FU was also validated in xenograft tumour model (Figure 6G)...
Secondary therapy:
5-fluorouracil
DOI:
https://doi.org/10.1111/jcmm.17640
