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Association details:
| Biomarker: | KIT W557_V559delinsF |
|---|---|
| Cancer: | Gastrointestinal Stromal Tumor |
| Drug: | plocabulin (PM184) (Microtubule inhibitor, Tubulin binding agent) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors
Published date:
07/22/2020
Excerpt:
UZLX-GIST3KIT 11 harbored KIT mutation in exon 11 (p.W557_V559delinsF),...Plocabulin treatment resulted in statistically significant tumor regression in UZLX-GIST3KIT 11 and UZLX-GIST9FKIT 11+17. Tumors of UZLX-GIST3KIT 11 treated with plocabulin shrank to 64% of baseline volume (p = 0.02, Wilcoxon matched-pairs signed rank test, WMP),...
DOI:
https://doi.org/10.1016/j.tranon.2020.100832
