^
Association details:
| Biomarker: | KIT W557_V559delinsF |
|---|---|
| Cancer: | Gastrointestinal Stromal Tumor |
| Drug: | imatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, PDGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors
Published date:
07/22/2020
Excerpt:
Expectedly, imatinib treatment resulted in tumor volume reduction in UZLX-GIST3KIT 11, the imatinib-sensitive model with KIT exon 11 mutation, while having no effect on UZLX-GIST9FKIT 11+17, the model with double KIT exon 11 and 17 mutations.
DOI:
https://doi.org/10.1016/j.tranon.2020.100832
