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    Association details:
    Biomarker:KIT P577del + KIT W557Lfs*5 + KIT Y823D
    Cancer:Gastrointestinal Stromal Tumor
    Drug:plocabulin (PM184) (Microtubule inhibitor, Tubulin binding agent)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    ScienceDirect
    Title:

    Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors

    Published date:
    07/22/2020
    Excerpt:
    ...UZLX-GIST9FKIT 11+17 harbored mutations in exons 11 and 17 (p.P577del;W557LfsX5;Y823D)…Plocabulin treatment resulted in statistically significant tumor regression in UZLX-GIST3KIT 11 and UZLX-GIST9FKIT 11+17...those of UZLX-GIST9FKIT 11+17 shrank to 44% (p = 0.03, WMP).
    DOI:
    https://doi.org/10.1016/j.tranon.2020.100832