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Association details:
| Biomarker: | KIT P577del + KIT W557Lfs*5 + KIT Y823D |
|---|---|
| Cancer: | Gastrointestinal Stromal Tumor |
| Drug: | imatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, PDGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors
Published date:
07/22/2020
Excerpt:
...UZLX-GIST9FKIT 11+17 harbored mutations in exons 11 and 17 (p.P577del;W557LfsX5;Y823D)…Expectedly, imatinib treatment resulted in tumor volume reduction in UZLX-GIST3KIT 11, the imatinib-sensitive model with KIT exon 11 mutation, while having no effect on UZLX-GIST9FKIT 11+17, the model with double KIT exon 11 and 17 mutations.
DOI:
https://doi.org/10.1016/j.tranon.2020.100832
