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Association details:
| Biomarker: | KIT mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
1071P - Trustworthy artificial intelligence models using real-world and circulating genomics data for the prediction of immunotherapy efficacy in non-small cell lung cancer patients
Published date:
09/05/2022
Excerpt:
Among 480 advanced NSCLC patients (pts) treated with IO at Istituto Nazionale Tumori of Milan, 113 pts who performed cell-free DNA sequencing....PD-L1 positively correlated with DCR, ORR and OS. Among the G features, SHAP detected TP53 as the most relevant gene negatively correlated with outcome. KIT gene was identified as the second most important gene negatively correlated with the outcomes. BRAF was found to correlate with worse response....The explainable AI algorithms suggested a negative predictive role of TP53 and KIT mutational status.
