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    Association details:
    Biomarker:KIT K642E
    Cancer:Melanoma
    Drug:dasatinib (c-KIT inhibitor, Bcr-abl tyrosine kinase inhibitor, Src kinase inhibitor, EphA2 receptor antagonist, PDGFR β antagonist)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    ACS Publications
    Title:

    A phase II trial of dasatinib in advanced melanoma

    Excerpt:
    Only one responder, a patient with a primary subungual melanoma, had a K642E substitution mutation in exon 13 of c-kit.
    DOI:
    10.1002/cncr.25766