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Association details:
| Biomarker: | KIT exon 9 mutation |
|---|---|
| Cancer: | Gastrointestinal Stromal Tumor |
| Drug: | IPI 493 (HSP90 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations
Excerpt:
When administered as a single agent in a xenograft model, the HSP90 inhibitor IPI-493 has consistent antitumor activity and induces KIT downregulation in GISTs with heterogeneous KIT mutations....the efficacy of IPI-493 is better than IMA in GIST carrying a KIT exon 9 isoform.
DOI:
10.1158/1078-0432.CCR-11-0562
