A 28-year-old male presented with jejunal GIST...Mutation testing was suggestive of exon 17 mutation in the c-KIT domain….After a discussion in the tumor board, the patient was started on avapritinib. He tolerated avapritinib well with greying of hairs and transaminitis (grade 2). A scan was done post 3 months for response evaluation and showed a complete metabolic response and stable disease (Figure 1). The therapy was continued, however, another response assessment was done at 6 months showed PD (Figure 2).