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Association details:
| Biomarker: | KIT exon 13 mutation |
|---|---|
| Cancer: | Gastrointestinal Stromal Tumor |
| Drug: | IDRX-42 (c-KIT inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1514P - Anti-tumor effects of the novel KIT mutant inhibitor M4205 in gastrointestinal stromal tumor (GIST) xenograft models
Published date:
09/05/2022
Excerpt:
M4205 has significant antitumor activity in patient- and cell line-derived GIST xenograft models. The novel kinase inhibitor induces volumetric responses, decreases mitotic activity, has antiproliferative effects and in models with KIT exon 13 mutation leads to characteristic myxoid degeneration.
