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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
Title:

EP08.02-037 - Small Cell Transformation in a Patient with RET Fusion Positive Lung Adenocarcinoma on Pralsetinib.

Published date:
07/12/2022
Excerpt:
A 72-year-old never smoker male patient was diagnosed with lung adenocarcinoma...Molecular workup (MCSTP) identified a KIF5B::RET fusion along with a loss-of-function mutation in TP53 (H193R) and MYC amplification….Pralsetinib was resumed following completion of radiation therapy, however further progression was detected 2 months later in the chest, abdomen and brain with fistula formation between the right mainstem bronchus and the subcarinal lymph node block.