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Association details:
| Biomarker: | JAK2 R683G |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | sirolimus (mTOR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
Excerpt:
Rapamycin significantly prolonged survival compared with vehicle of both xenograft IV (Figure 5A, median survival 63 days vs 23 days, P < .01) and xenograft V (Figure 5B, median survival 91 days vs 58 days, P < .01).
DOI:
10.1182%2Fblood-2012-03-415448
