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Association details:
| Biomarker: | ITGAM expression |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Onureg (azacitidine oral) (DNMT inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
CC-486 Mechanism Imparted By Extended Exposure of Azacitidine Upregulates Myeloid Differentiation Markers and Induces Cell Death in AML Cells
Published date:
11/04/2020
Excerpt:
Tx of AML-193 cells with 0.05 - 5 µM daily AZA led to upregulation of markers of myeloid differentiation (including CD11b) at lower doses, and a dose-dependent increase in apoptosis up to 7d after Tx initiation….These results suggest that CC-486-mediated effects using extended exposure regimens preferentially promote a differentiation effect and cell death of AML tumor cells.
DOI:
https://doi.org/10.1182/blood-2020-137606
