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DRUG:

Istodax (romidepsin)

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Company:

Astellas, BMS

Drug class:

HDAC inhibitor

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No biomarker	Peripheral T-cell Lymphoma	No biomarker	Peripheral T-cell Lymphoma	romidepsin Sensitive: A2 - Guideline romidepsin Sensitive : A2	romidepsin Sensitive: A2 - Guideline romidepsin Sensitive : A2
ERBB3 overexpression	Triple Negative Breast Cancer	ERBB3 overexpression	Triple Negative Breast Cancer	romidepsin Sensitive: C3 – Early Trials romidepsin Sensitive : C3	romidepsin Sensitive: C3 – Early Trials romidepsin Sensitive : C3
DNMT3A mutation	Lymphoma	DNMT3A mutation	Lymphoma	azacitidine + romidepsin Sensitive: C3 – Early Trials azacitidine + romidepsin Sensitive : C3	azacitidine + romidepsin Sensitive: C3 – Early Trials azacitidine + romidepsin Sensitive : C3
IDH2 mutation	Lymphoma	IDH2 mutation	Lymphoma	azacitidine + romidepsin Sensitive: C3 – Early Trials azacitidine + romidepsin Sensitive : C3	azacitidine + romidepsin Sensitive: C3 – Early Trials azacitidine + romidepsin Sensitive : C3
TET2 mutation	Lymphoma	TET2 mutation	Lymphoma	azacitidine + romidepsin Sensitive: C3 – Early Trials azacitidine + romidepsin Sensitive : C3	azacitidine + romidepsin Sensitive: C3 – Early Trials azacitidine + romidepsin Sensitive : C3
IDH2 mutation	Glioma	IDH2 mutation	Glioma	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D
IDH1 mutation	Glioma	IDH1 mutation	Glioma	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D
MDM2 amplification + CDK4 amplification	Liposarcoma	MDM2 amplification + CDK4 amplification	Liposarcoma	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D
TP53 deletion	B Acute Lymphoblastic Leukemia	TP53 deletion	B Acute Lymphoblastic Leukemia	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D	romidepsin Sensitive: D – Preclinical romidepsin Sensitive : D