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Association details:
| Biomarker: | IKZF1 deletion |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | cytarabine (DNA synthesis inhibitor, DNA-directed DNAP inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
LOSS OF IKZF1 CONTRIBUTES TO CYTARABINE RESISTANCE IN B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
Published date:
05/12/2021
Excerpt:
Together, these results demonstrate that loss of IKZF1 confers resistance to AraC, both in experimental models and in patient-derived cells.
