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Association details:
| Biomarker: | IGF1R expression |
|---|---|
| Cancer: | Ewing Sarcoma |
| Drug Class: | IGF-1R inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas
Excerpt:
This single centre series includes patients with unresectable or metastatic soft tissue sarcomas (STS), Ewing sarcoma (ES) and osteosarcoma treated with IGF-1R Ab...Exclusive nuclear localisation of IGF-1R is an easily testable biomarker associated with a better PFS and OS for patients treated with IGF-1R Ab therapy.
DOI:
10.1016/j.ejca.2012.05.009
