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DRUG CLASS:

IGF-2 inhibitor

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IGF-2 inhibitor

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HR positive	HER2 Negative Breast Cancer	HR positive	HER2 Negative Breast Cancer	everolimus + BI-836845 Sensitive: C3 – Early Trials everolimus + BI-836845 Sensitive : C3	everolimus + BI-836845 Sensitive: C3 – Early Trials everolimus + BI-836845 Sensitive : C3
HR positive	HER2 Negative Breast Cancer	HR positive	HER2 Negative Breast Cancer	abemaciclib + BI-836845 Sensitive: C3 – Early Trials abemaciclib + BI-836845 Sensitive : C3	abemaciclib + BI-836845 Sensitive: C3 – Early Trials abemaciclib + BI-836845 Sensitive : C3
IGF1 overexpression	Prostate Cancer	IGF1 overexpression	Prostate Cancer	enzalutamide capsule + BI-836845 Sensitive: C3 – Early Trials enzalutamide capsule + BI-836845 Sensitive : C3	enzalutamide capsule + BI-836845 Sensitive: C3 – Early Trials enzalutamide capsule + BI-836845 Sensitive : C3
PTEN overexpression	Prostate Cancer	PTEN overexpression	Prostate Cancer	enzalutamide capsule + BI-836845 Sensitive: C3 – Early Trials enzalutamide capsule + BI-836845 Sensitive : C3	enzalutamide capsule + BI-836845 Sensitive: C3 – Early Trials enzalutamide capsule + BI-836845 Sensitive : C3
IGF2 overexpression	Hepatocellular Cancer	IGF2 overexpression	Hepatocellular Cancer	BI-836845 Sensitive: D – Preclinical BI-836845 Sensitive : D	BI-836845 Sensitive: D – Preclinical BI-836845 Sensitive : D