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Association details:
Biomarker:IDH1 mutation
Cancer:Anaplastic Astrocytoma
Regimen: (lomustine + Matulane (procarbazine hydrochloride) + vincristine)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Radiotherapy-PCV versus radiotherapy-temozolomide for IDH-mutant anaplastic astrocytoma: a retrospective multicentre analysis of the French POLA cohort

Published date:
02/01/2021
Excerpt:
The 4‐year PFS in the RT + PCV arm was 70.8% versus 53.5% in the RT + TMZ arm...RT + PCV significantly improved PFS compared with RT + TMZ for IDH‐mutant AA.
DOI:
10.1002/onco.13701