^
Association details:
| Biomarker: | IDH1 mutation + BRAF V600E |
|---|---|
| Cancer: | Astrocytoma |
| Drug: | Mekinist (trametinib) (MEK inhibitor) + Tafinlar (dabrafenib) (BRAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Excerpt:
ADULT GLIOMA: IDH-MUTANT ASTROCYTOMA….Recurrent or Progressive Disease WHO grade 2, KPS ≥60...Useful in Certain Circumstances...BRAF V600E activation mutation...BRAF/MEK inhibitors:…Dabrafenib/trametinib
