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    Association details:
    Biomarker:HSPA6 expression
    Cancer:Esophageal Squamous Cell Carcinoma
    Drug:metformin (AMPK activator)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Oncology
    Title:

    Metformin-Induced Heat Shock Protein Family A Member 6 Is a Promising Biomarker of Esophageal Squamous Cell Carcinoma

    Published date:
    02/08/2022
    Excerpt:
    We examined metformin-induced mRNA expression changes in two human ESCC cell lines...The result indicated HSPA6 as a promising biomarker. HSPA6 expression correlated with disease-free survival (DFS) of the patients with all stage ESCC (p = 0.021), especially with stage I/II ESCC (p < 0.001)...This NGS analysis detected prospective candidate genes, including HSPA6. Our results indicate that HSPA6 is a promising biomarker of the recurrence risk of stage I/II ESCC.
    DOI:
    10.1159/000522446