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BIOMARKER:
HRD
i
Other names:
Homologous Recombination Deficiency
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Related biomarkers:
Others
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HRD + BRCA1 mutation (7)
HRD + BRCA2 mutation (7)
HRD + BRCA wild-type (6)
PTGR1 elevation + HRD (3)
HRD Signature-3 (2)
High HRD score (0)
HRD + BRCA1 mutation (7)
HRD + BRCA2 mutation (7)
HRD + BRCA wild-type (6)
PTGR1 elevation + HRD (3)
HRD Signature-3 (2)
High HRD score (0)
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HRD
Fallopian Tube Cancer
HRD
Fallopian Tube Cancer
bevacizumab + olaparib
Sensitive: A1 - Approval
bevacizumab + olaparib
Sensitive
:
A1
bevacizumab + olaparib
Sensitive: A1 - Approval
bevacizumab + olaparib
Sensitive
:
A1
HRD
Peritoneal Cancer
HRD
Peritoneal Cancer
bevacizumab + olaparib
Sensitive: A1 - Approval
bevacizumab + olaparib
Sensitive
:
A1
bevacizumab + olaparib
Sensitive: A1 - Approval
bevacizumab + olaparib
Sensitive
:
A1
HRD
Peritoneal Cancer
HRD
Peritoneal Cancer
niraparib
Sensitive: A1 - Approval
niraparib
Sensitive
:
A1
niraparib
Sensitive: A1 - Approval
niraparib
Sensitive
:
A1
HRD
Fallopian Tube Cancer
HRD
Fallopian Tube Cancer
niraparib
Sensitive: A1 - Approval
niraparib
Sensitive
:
A1
niraparib
Sensitive: A1 - Approval
niraparib
Sensitive
:
A1
HRD
Ovarian Cancer
HRD
Ovarian Cancer
bevacizumab + olaparib
Sensitive: A1 - Approval
bevacizumab + olaparib
Sensitive
:
A1
bevacizumab + olaparib
Sensitive: A1 - Approval
bevacizumab + olaparib
Sensitive
:
A1
HRD
Ovarian Cancer
HRD
Ovarian Cancer
niraparib
Sensitive: A1 - Approval
niraparib
Sensitive
:
A1
niraparib
Sensitive: A1 - Approval
niraparib
Sensitive
:
A1
HRD
Prostate Cancer
HRD
Prostate Cancer
olaparib
Sensitive: A1 - Approval
olaparib
Sensitive
:
A1
olaparib
Sensitive: A1 - Approval
olaparib
Sensitive
:
A1
HRD
Prostate Cancer
HRD
Prostate Cancer
talazoparib + enzalutamide capsule
Sensitive: A1 - Approval
talazoparib + enzalutamide capsule
Sensitive
:
A1
talazoparib + enzalutamide capsule
Sensitive: A1 - Approval
talazoparib + enzalutamide capsule
Sensitive
:
A1
HRD
Ovarian Cancer
HRD
Ovarian Cancer
rucaparib
Sensitive: A2 - Guideline
rucaparib
Sensitive
:
A2
rucaparib
Sensitive: A2 - Guideline
rucaparib
Sensitive
:
A2
HRD
Ovarian Cancer
HRD
Ovarian Cancer
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
HRD
Ovarian Cancer
HRD
Ovarian Cancer
olaparib
Sensitive: B - Late Trials
olaparib
Sensitive
:
B
olaparib
Sensitive: B - Late Trials
olaparib
Sensitive
:
B
HRD
Ovarian Cancer
HRD
Ovarian Cancer
ABT-888
Sensitive: B - Late Trials
ABT-888
Sensitive
:
B
ABT-888
Sensitive: B - Late Trials
ABT-888
Sensitive
:
B
HRD
Ovarian Cancer
HRD
Ovarian Cancer
atezolizumab
Resistant: B - Late Trials
atezolizumab
Resistant
:
B
atezolizumab
Resistant: B - Late Trials
atezolizumab
Resistant
:
B
HRD
Ovarian Cancer
HRD
Ovarian Cancer
Sensitive: B - Late Trials
Sensitive
:
B
Sensitive: B - Late Trials
Sensitive
:
B
HRD
Breast Cancer
HRD
Breast Cancer
CX-5461
Sensitive: B - Late Trials
CX-5461
Sensitive
:
B
CX-5461
Sensitive: B - Late Trials
CX-5461
Sensitive
:
B
HRD
Ovarian Cancer
HRD
Ovarian Cancer
CX-5461
Sensitive: B - Late Trials
CX-5461
Sensitive
:
B
CX-5461
Sensitive: B - Late Trials
CX-5461
Sensitive
:
B
HRD
Prostate Cancer
HRD
Prostate Cancer
niraparib
Sensitive: B - Late Trials
niraparib
Sensitive
:
B
niraparib
Sensitive: B - Late Trials
niraparib
Sensitive
:
B
HRD
Triple Negative Breast Cancer
HRD
Triple Negative Breast Cancer
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
olaparib
Sensitive: C1 - Off-label
olaparib
Sensitive
:
C1
HRD
HER2 Negative Breast Cancer
HRD
HER2 Negative Breast Cancer
olaparib
Resistant: C1 - Off-label
olaparib
Resistant
:
C1
olaparib
Resistant: C1 - Off-label
olaparib
Resistant
:
C1
HRD
Ovarian Cancer
HRD
Ovarian Cancer
tislelizumab-jsgr + pamiparib
Sensitive: C2 – Inclusion Criteria
tislelizumab-jsgr + pamiparib
Sensitive
:
C2
tislelizumab-jsgr + pamiparib
Sensitive: C2 – Inclusion Criteria
tislelizumab-jsgr + pamiparib
Sensitive
:
C2
HRD
Triple Negative Breast Cancer
HRD
Triple Negative Breast Cancer
tislelizumab-jsgr
Sensitive: C2 – Inclusion Criteria
tislelizumab-jsgr
Sensitive
:
C2
tislelizumab-jsgr
Sensitive: C2 – Inclusion Criteria
tislelizumab-jsgr
Sensitive
:
C2
HRD
Ovarian Cancer
HRD
Ovarian Cancer
bevacizumab + niraparib
Sensitive: C2 – Inclusion Criteria
bevacizumab + niraparib
Sensitive
:
C2
bevacizumab + niraparib
Sensitive: C2 – Inclusion Criteria
bevacizumab + niraparib
Sensitive
:
C2
HRD
Ovarian Cancer
HRD
Ovarian Cancer
IDE161
Sensitive: C2 – Inclusion Criteria
IDE161
Sensitive
:
C2
IDE161
Sensitive: C2 – Inclusion Criteria
IDE161
Sensitive
:
C2
HRD
Breast Cancer
HRD
Breast Cancer
IDE161
Sensitive: C2 – Inclusion Criteria
IDE161
Sensitive
:
C2
IDE161
Sensitive: C2 – Inclusion Criteria
IDE161
Sensitive
:
C2
HRD
Triple Negative Breast Cancer
HRD
Triple Negative Breast Cancer
olaparib + durvalumab
Sensitive: C2 – Inclusion Criteria
olaparib + durvalumab
Sensitive
:
C2
olaparib + durvalumab
Sensitive: C2 – Inclusion Criteria
olaparib + durvalumab
Sensitive
:
C2
HRD
Non Small Cell Lung Cancer
HRD
Non Small Cell Lung Cancer
talazoparib
Resistant: C3 – Early Trials
talazoparib
Resistant
:
C3
talazoparib
Resistant: C3 – Early Trials
talazoparib
Resistant
:
C3
HRD
Gastric Cancer
HRD
Gastric Cancer
nivolumab
Sensitive: C3 – Early Trials
nivolumab
Sensitive
:
C3
nivolumab
Sensitive: C3 – Early Trials
nivolumab
Sensitive
:
C3
HRD
Triple Negative Breast Cancer
HRD
Triple Negative Breast Cancer
pembrolizumab + niraparib
Sensitive: C3 – Early Trials
pembrolizumab + niraparib
Sensitive
:
C3
pembrolizumab + niraparib
Sensitive: C3 – Early Trials
pembrolizumab + niraparib
Sensitive
:
C3
HRD
Prostate Cancer
HRD
Prostate Cancer
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
HRD
Prostate Cancer
HRD
Prostate Cancer
abiraterone acetate
Resistant: C3 – Early Trials
abiraterone acetate
Resistant
:
C3
abiraterone acetate
Resistant: C3 – Early Trials
abiraterone acetate
Resistant
:
C3
HRD
Ovarian Cancer
HRD
Ovarian Cancer
ABT-767
Sensitive: C3 – Early Trials
ABT-767
Sensitive
:
C3
ABT-767
Sensitive: C3 – Early Trials
ABT-767
Sensitive
:
C3
HRD
Ovarian Cancer
HRD
Ovarian Cancer
PARP inhibitor
Sensitive: C3 – Early Trials
PARP inhibitor
Sensitive
:
C3
PARP inhibitor
Sensitive: C3 – Early Trials
PARP inhibitor
Sensitive
:
C3
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